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| Home | Research | Mount Holyoke
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Liverpool | |
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Ultimate Goal: |
To understand the molecular level structure of peptides associated with diseases. | ||
| Techniques Employed: | Isotope edited infrared spectroscopy Atomic Force Microscopy Solid phase peptide synthesis |
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| Peptides Studied: | Residues 109-122 of the Prion peptide, associated with BSE. Residues 16-22 of the Amyloid Beta peptide, associated with Alzheimer's disease. |
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| Main Findings: | Both peptides form b-sheet aggregates, which are shown to have a very specific alignment, which affects the stability and type of aggregates formed. The kinetics of the alignment process are highly dependent on concentration, providing insites into the alignment mechanism. |
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| Advisor: | Prof. Sean Decatur | |||